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- Publisher: Humana
- ISBN-10: 1071617397
- ISBN-13: 9781071617397
- Format: 20.3 x 25.9 x 2.3 cm, hardcover
- Language: English
- SAVE -10% with code: EXTRA
Mapping Genetic Interactions (e-book) (used book) | bookbook.eu
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Part I: Mapping Genetic Interactions in Model Systems
1. Quantitative Genetic Screens for Mapping Bacterial Pathways and Functional Networks
Alla Gagarinova, Ali Hosseinnia, and Mohan Babu
2. Mapping Synthetic Dosage Lethal Genetic Interactions in Saccharomyces cerevisiae
Akil Hamza, Leanne Amitzi, Supipi Duffy, and Philip Hieter
3. Systematic High-Content Screening of Fluorescently-Tagged Yeast Double Mutant Strains
Harsha Garadi Suresh and Mojca Mattiazzi Usaj
4. A Genetic Interaction Screening Approach in C. elegans
John A. Calarco
5. RNA Interference (RNAi) Screening in Cultured Drosophila Cells
Juan-Carlos A. Padilla, Ashley Chin, Dhara Patel, Xiaofeng Wang, Philippe Jolivet, and Eric Lécuyer
Part II: Approaches to Map Genetic Interactions in Human cells
6. Employing Cross-Species Approaches to Construct Humanized Genetic Interaction Networks
Lucile M. Jeusset and Kirk J. McManus
7. Identification of Synthetic Lethal Interactions Using High-Throughput, Arrayed CRISPR/Cas9-based Platforms
Mackenzie J. MacAuley, Omar Abuhussein, and Frederick S. Vizeacoumar
8. Exploring Candidate Human Synthetic Lethal Interactions Through siRNA and Quantitative Imaging-Based Approaches
Lucile M. Jeusset and Kirk J. McManus
9. Mapping Genetic Interactions in Human Cancer Cells Using a One-Step tRNA-CRISPR System
Derek Yisen Zhang, Xiong Gui, and Xiaolong Yang
10. In vivo Genome-Wide Pooled RNAi Screens in Cancer Cells to Identify Determinants of Chemotherapy/Drug Response
Margaret L Dahn and Paola Marcato
Part III: Predicting Genetic Interactions Using Computational Approaches
11. INCISOR: An Algorithm to Identify Synthetic Rescue Mediators of Resistance to Targeted and Immunotherapy
Xiaoman Wang, Frederick Sagayaraj Vizeacoumar, and Avinash Das Sahu
12. Machine Learning to Identify Gene Interactions from High-Throughput Mutant CrossesAshwani Kumar, Andrew Cameron, and Sandra Zilles
13. Identification of Drug Resistance Genes Using a Pooled Lentiviral CRISPR/Cas9 Screening Approach
Evan M. Kerek, Christopher R. Cromwell, and Basil P. Hubbard
14. Chemical Genetic Interactions as a Means to Characterize Drug Synergy
Hamid Gaikani, Guri Giaever, and Corey Nislow
Part V: Emerging Technologies that Leverage Mapping Genetic Interactions
15. Puromycin Labeling Coupled with Proximity Ligation Assays to Define Sites of mRNA Translation in Drosophila Embryos and Human CellsAshley Chin and Eric Lécuyer
16. Inferring Copy Number from Triple Negative Breast Cancer Patient Derived Xenograft scRNAseq Data using scCNAutils
Elena Kuzmin, Jean Monlong, Constanza Martinez Ramirez, Hellen Kuasne, Claudia L. Kleinman, Jiannis Ragoussis, Guillaume Bourque, and Morag Park
Part VI: Downstream Validation of Genetic Interactions using Protein Inhibitors and Small Molecules
17. Generation of Protein Inhibitors for Validation of Cancer Drug Targets Identified in Functional Genomic Screens
Sherin McDonald, Arunkumar Annan Sudarsan, Hanan Babeker, Kiranmayee Budharaju, and Maruti Uppalapati
18. Computational Prediction of Chemical Tools for Identification and Validation of Synthetic Lethal Interaction Networks
Kalpana K B
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- Publisher: Humana
- ISBN-10: 1071617397
- ISBN-13: 9781071617397
- Format: 20.3 x 25.9 x 2.3 cm, hardcover
- Language: English English
Part I: Mapping Genetic Interactions in Model Systems
1. Quantitative Genetic Screens for Mapping Bacterial Pathways and Functional Networks
Alla Gagarinova, Ali Hosseinnia, and Mohan Babu
2. Mapping Synthetic Dosage Lethal Genetic Interactions in Saccharomyces cerevisiae
Akil Hamza, Leanne Amitzi, Supipi Duffy, and Philip Hieter
3. Systematic High-Content Screening of Fluorescently-Tagged Yeast Double Mutant Strains
Harsha Garadi Suresh and Mojca Mattiazzi Usaj
4. A Genetic Interaction Screening Approach in C. elegans
John A. Calarco
5. RNA Interference (RNAi) Screening in Cultured Drosophila Cells
Juan-Carlos A. Padilla, Ashley Chin, Dhara Patel, Xiaofeng Wang, Philippe Jolivet, and Eric Lécuyer
Part II: Approaches to Map Genetic Interactions in Human cells
6. Employing Cross-Species Approaches to Construct Humanized Genetic Interaction Networks
Lucile M. Jeusset and Kirk J. McManus
7. Identification of Synthetic Lethal Interactions Using High-Throughput, Arrayed CRISPR/Cas9-based Platforms
Mackenzie J. MacAuley, Omar Abuhussein, and Frederick S. Vizeacoumar
8. Exploring Candidate Human Synthetic Lethal Interactions Through siRNA and Quantitative Imaging-Based Approaches
Lucile M. Jeusset and Kirk J. McManus
9. Mapping Genetic Interactions in Human Cancer Cells Using a One-Step tRNA-CRISPR System
Derek Yisen Zhang, Xiong Gui, and Xiaolong Yang
10. In vivo Genome-Wide Pooled RNAi Screens in Cancer Cells to Identify Determinants of Chemotherapy/Drug Response
Margaret L Dahn and Paola Marcato
Part III: Predicting Genetic Interactions Using Computational Approaches
11. INCISOR: An Algorithm to Identify Synthetic Rescue Mediators of Resistance to Targeted and Immunotherapy
Xiaoman Wang, Frederick Sagayaraj Vizeacoumar, and Avinash Das Sahu
12. Machine Learning to Identify Gene Interactions from High-Throughput Mutant CrossesAshwani Kumar, Andrew Cameron, and Sandra Zilles
13. Identification of Drug Resistance Genes Using a Pooled Lentiviral CRISPR/Cas9 Screening Approach
Evan M. Kerek, Christopher R. Cromwell, and Basil P. Hubbard
14. Chemical Genetic Interactions as a Means to Characterize Drug Synergy
Hamid Gaikani, Guri Giaever, and Corey Nislow
Part V: Emerging Technologies that Leverage Mapping Genetic Interactions
15. Puromycin Labeling Coupled with Proximity Ligation Assays to Define Sites of mRNA Translation in Drosophila Embryos and Human CellsAshley Chin and Eric Lécuyer
16. Inferring Copy Number from Triple Negative Breast Cancer Patient Derived Xenograft scRNAseq Data using scCNAutils
Elena Kuzmin, Jean Monlong, Constanza Martinez Ramirez, Hellen Kuasne, Claudia L. Kleinman, Jiannis Ragoussis, Guillaume Bourque, and Morag Park
Part VI: Downstream Validation of Genetic Interactions using Protein Inhibitors and Small Molecules
17. Generation of Protein Inhibitors for Validation of Cancer Drug Targets Identified in Functional Genomic Screens
Sherin McDonald, Arunkumar Annan Sudarsan, Hanan Babeker, Kiranmayee Budharaju, and Maruti Uppalapati
18. Computational Prediction of Chemical Tools for Identification and Validation of Synthetic Lethal Interaction Networks
Kalpana K B
Reviews