- We will send in 10–14 business days.
/images/books/13013831/9783038427049.jpg)
- Publisher: MDPI AG
- ISBN-10: 3038427047
- ISBN-13: 9783038427049
- Format: 17 x 24.4 x 0.9 cm, minkšti viršeliai
- Language: English
- SAVE -10% with code: EXTRA
Cellular Entry of Binary and Pore-Forming Bacterial Toxins (e-book) (used book) | bookbook.eu
Reviews
Description
Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein-lipid and protein-protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification.
This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues.
EXTRA 10 % discount with code: EXTRA
The promotion ends in 23d.21:20:13
The discount code is valid when purchasing from 10 €. Discounts do not stack.
- Publisher: MDPI AG
- ISBN-10: 3038427047
- ISBN-13: 9783038427049
- Format: 17 x 24.4 x 0.9 cm, minkšti viršeliai
- Language: English English
Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein-lipid and protein-protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification.
This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues.
Reviews