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- Author: Ammar Khawam
- Publisher: VDM Verlag
- ISBN-10: 3639091140
- ISBN-13: 9783639091144
- Format: 15.2 x 22.9 x 1.9 cm, minkšti viršeliai
- Language: English
- SAVE -10% with code: EXTRA
Application of Solid-State Kinetics to Desolvation Reactions (e-book) (used book) | bookbook.eu
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The book presents an overview of the solid-state kinetic literature in-cluding methodologies used, mathematical derivations and pharma-ceutical applications. The book investigates the relationship between calculation methods and artifactual results observed in solid-state kinetics. A new approach is proposed for evaluating solid-state kinetic data, this approach combines modelistic and model-free methods in a complimentary manner to achieve consistent kinetic results. Experimental data focused on studying the solid-state stability of several structurally related solvates of sulfameter (5-methoxysulfadiazine), this was done by studying the kinetics of their desolvation reaction both isothermally and nonisothermally. Calculated kinetic parameters were compared and related to the crystal structure of these solvates. A relationship was established between desolvation kinetic parameters (e.g., activation energy) and the solvent size. The solid-state reaction models selected also corresponded to the single crystal structure of the sulfameter-solvate system.
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- Author: Ammar Khawam
- Publisher: VDM Verlag
- ISBN-10: 3639091140
- ISBN-13: 9783639091144
- Format: 15.2 x 22.9 x 1.9 cm, minkšti viršeliai
- Language: English English
The book presents an overview of the solid-state kinetic literature in-cluding methodologies used, mathematical derivations and pharma-ceutical applications. The book investigates the relationship between calculation methods and artifactual results observed in solid-state kinetics. A new approach is proposed for evaluating solid-state kinetic data, this approach combines modelistic and model-free methods in a complimentary manner to achieve consistent kinetic results. Experimental data focused on studying the solid-state stability of several structurally related solvates of sulfameter (5-methoxysulfadiazine), this was done by studying the kinetics of their desolvation reaction both isothermally and nonisothermally. Calculated kinetic parameters were compared and related to the crystal structure of these solvates. A relationship was established between desolvation kinetic parameters (e.g., activation energy) and the solvent size. The solid-state reaction models selected also corresponded to the single crystal structure of the sulfameter-solvate system.
Reviews