- We will send in 10–14 business days.
/images/books/13375657/9783838116716.jpg)
- Author: Christian Joffroy
- Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
- Year: 2010
- Pages: 116
- ISBN-10: 3838116712
- ISBN-13: 9783838116716
- Format: 15.2 x 22.9 x 0.7 cm, minkšti viršeliai
- Language: English
- SAVE -10% with code: EXTRA
Reviews
Description
Antiestrogens (AE) like tamoxifen belong to the most commonly used drugs in the therapy of estrogen receptor positive breast cancer. Nevertheless, relapses frequently occur during treatment indicating development of drug resistance. Concerning the underlying mechanisms, the finding of AE induced TGFÃ in breast cancer cells appears to be relevant both with respect to TGFÃ's cell autonomous function as a mediator of cancer progression and its function as an immune regulator. To investigate the potential role of tumor derived, AE induced TGFÃ as a suppressor of the host's immune response, heterologous and autologous in vitro assays have been established in this work. Application of AE led to an impaired antitumor immune response, which could be restored by a neutralizing TGFÃ antibody. The work at hand thus provides evidence for an AE treatment induced, TGFÃ driven immunosuppression in the tumor microenvironment, a mechanism that could critically contribute to development of AE resistance during therapy.
EXTRA 10 % discount with code: EXTRA
The promotion ends in 21d.06:27:48
The discount code is valid when purchasing from 10 €. Discounts do not stack.
- Author: Christian Joffroy
- Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
- Year: 2010
- Pages: 116
- ISBN-10: 3838116712
- ISBN-13: 9783838116716
- Format: 15.2 x 22.9 x 0.7 cm, minkšti viršeliai
- Language: English English
Antiestrogens (AE) like tamoxifen belong to the most commonly used drugs in the therapy of estrogen receptor positive breast cancer. Nevertheless, relapses frequently occur during treatment indicating development of drug resistance. Concerning the underlying mechanisms, the finding of AE induced TGFÃ in breast cancer cells appears to be relevant both with respect to TGFÃ's cell autonomous function as a mediator of cancer progression and its function as an immune regulator. To investigate the potential role of tumor derived, AE induced TGFÃ as a suppressor of the host's immune response, heterologous and autologous in vitro assays have been established in this work. Application of AE led to an impaired antitumor immune response, which could be restored by a neutralizing TGFÃ antibody. The work at hand thus provides evidence for an AE treatment induced, TGFÃ driven immunosuppression in the tumor microenvironment, a mechanism that could critically contribute to development of AE resistance during therapy.
Reviews